Sodium Hydroxide → HCID 178507234, compound

HRID 1381117Notes

Reaction equation

HRID 1381117 reaction equation
[N+:1]([C:4]1[CH:13]=[CH:12][C:11]2[NH:10][C:9](=[O:14])[N:8]3[CH2:15][CH2:16][N:17]=[C:7]3[C:6]=2[CH:5]=1)([O-])=O.[OH-].[Na+].S(S([O-])=O)([O-])=O.[Na+].[Na+]>O>[NH2:1][C:4]1[CH:13]=[CH:12][C:11]2[NH:10][C:9](=[O:14])[N:8]3[CH2:15][CH2:16][N:17]=[C:7]3[C:6]=2[CH:5]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 24489Sodium DithioniteHCID 178517283HCID 178517283, compound

Product 1

HCID 178507234HCID 178507234, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
60 °C

Procedure

4.6 g of 9-nitro-5-oxo-2,3,5,6-tetrahydroimidazo-[1,2-c]-quinazoline were dissolved in 4.8 g (0.12 mol) of NaOH in 80 ml of H2O. 10.5 g of sodium dithionite were added to the mixture, during which the temperature increased to 60° C. The mixture was then heated to boiling for a short time. After the mixture had been cooled, the precipitated crystals were filtered off under suction, washed with H2O and finally thoroughly stirred in 1N NaOH. The mixture was then again filtered off under suction, and the residue was washed with water, ethanol and ether, and dried.

Workup

  1. temperatureThe mixture was then heated
  2. temperatureAfter the mixture had been cooled
  3. filtrationthe precipitated crystals were filtered off under suction
  4. washwashed with H2O
  5. filtrationThe mixture was then again filtered off under suction
  6. washthe residue was washed with water, ethanol and ether
  7. customdried

Sources & evidence

ORD record
ord-dd6feb43da0f474599578bdc83a02a96
Source dataset
uspto-grants-1986_04
Patent number
US04585772

Reaction notes

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