Isovaleryl chloride → HCID 178447203, compound

HRID 1381118Notes

Reaction equation

HRID 1381118 reaction equation
[C:1](Cl)(=[O:6])[CH2:2][CH:3]([CH3:5])[CH3:4].[NH2:8][C:9]1[CH:18]=[CH:17][C:16]2[NH:15][C:14](=[O:19])[N:13]3[CH2:20][CH2:21][N:22]=[C:12]3[C:11]=2[CH:10]=1>N1C=CC=CC=1.CCOCC>[C:1]([NH:8][C:9]1[CH:18]=[CH:17][C:16]2[NH:15][C:14](=[O:19])[N:13]3[CH2:20][CH2:21][N:22]=[C:12]3[C:11]=2[CH:10]=1)(=[O:6])[CH2:2][CH:3]([CH3:5])[CH3:4]

Participants

5

Reactant 2

HCID 66054Isovaleryl chlorideHCID 178507234HCID 178507234, compound

Product 1

HCID 178447203HCID 178447203, compound

Reagents, catalysts & solvents 2

HCID 1049PyridineSolventHCID 3283Diethyl EtherSolvent

Procedure

2.5 g (0.02 mol) of isovaleric acid chloride were added to 2.02 g (0.01 mol) of 9-amino-5-oxo-2,3,5,6-tetrahydroimidazo-[1,2-c]-quinazoline in 30 ml of absolute pyridine, and the mixture was stirred for 8 hours at room temperature. The mixture was then diluted with ether, and the precipitated crystals were separated off. The crystals were dissolved in water, the aqueous solution was purified with active charcoal and the free base was then precipitated by the addition of ammonia. It was filtered off under suction and dried.

Workup

  1. customthe precipitated crystals were separated off
  2. dissolutionThe crystals were dissolved in water
  3. customthe aqueous solution was purified with active charcoal
  4. customthe free base was then precipitated by the addition of ammonia
  5. filtrationIt was filtered off under suction
  6. customdried

Sources & evidence

ORD record
ord-ec6258d8e67048d09f463b426f250d64
Source dataset
uspto-grants-1986_04
Patent number
US04585772

Reaction notes

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