Morpholine → HCID 178517308, compound

HRID 1381119Notes

Reaction equation

HRID 1381119 reaction equation
[O:1]=[C:2]1[N:11]2[CH2:12][CH2:13][N:14]=[C:10]2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[NH:3]1.Cl[S:16]([OH:19])(=O)=[O:17].[NH:20]1[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1>O>[N:20]1([S:16]([C:7]2[CH:6]=[CH:5][C:4]3[NH:3][C:2](=[O:1])[N:11]4[CH2:12][CH2:13][N:14]=[C:10]4[C:9]=3[CH:8]=2)(=[O:19])=[O:17])[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1

Participants

5

Reactant 3

HCID 8083MorpholineHCID 24638Chlorosulfonic acidHCID 178517111HCID 178517111, compound

Product 1

HCID 178517308HCID 178517308, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

30 mmols of 5-oxo-2,3,5,6-tetrahydroimidazo-[1,2-c]-quinazoline were added, whilst cooling with ice, to 20 ml of chlorosulphonic acid, and the mixture was stirred for 3 hours at 50° to 60° C. After this solution had been cooled, it was carefully added dropwise to 80 ml of cooled morpholine, and the mixture was thereafter diluted with 150 ml of water. The residue was filtered off under suction, washed with water and boiled up with alcohol.

Workup

  1. temperatureAfter this solution had been cooled
  2. filtrationThe residue was filtered off under suction
  3. washwashed with water

Sources & evidence

ORD record
ord-e67586a636cd4cbabf26e43ff39fce2a
Source dataset
uspto-grants-1986_04
Patent number
US04585772

Reaction notes

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