Benzenesulfonyl chloride → HCID 178517284, compound

HRID 1381120Notes

Reaction equation

HRID 1381120 reaction equation
[C:1]1([S:7](Cl)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:11][C:12]1[CH:21]=[CH:20][C:19]2[NH:18][C:17](=[O:22])[N:16]3[CH2:23][CH2:24][N:25]=[C:15]3[C:14]=2[CH:13]=1>N1C=CC=CC=1>[C:1]1([S:7]([NH:11][C:12]2[CH:21]=[CH:20][C:19]3[NH:18][C:17](=[O:22])[N:16]4[CH2:23][CH2:24][N:25]=[C:15]4[C:14]=3[CH:13]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 7369Benzenesulfonyl chlorideHCID 178507234HCID 178507234, compound

Product 1

HCID 178517284HCID 178517284, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

7.1 g of benzenesulphonic acid chloride were added to 4.04 g of 9-amino-5-oxo-2,3,5,6-tetrahydroimidazo-[1,2-c]-quinazoline in 50 ml of absolute pyridine, whilst cooling with ice. The cooling was removed and the mixture was stirred for 2 hours at room temperature. A large quantity of H2O was then added to the reaction mixture, and the precipitated crystals were filtered off under suction. The crystals were dissolved in aqueous NH3 and the solution was clarified using active charcoal and neutralised using hydrochloric acid.

Workup

  1. temperaturewhilst cooling with ice
  2. customThe cooling was removed
  3. additionA large quantity of H2O was then added to the reaction mixture
  4. filtrationthe precipitated crystals were filtered off under suction
  5. dissolutionThe crystals were dissolved in aqueous NH3

Sources & evidence

ORD record
ord-61f382a07d774e67a72cfbb480de06d1
Source dataset
uspto-grants-1986_04
Patent number
US04585772

Reaction notes

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