Bromine → HCID 54007007, compound

HRID 1381134Notes

Reaction equation

HRID 1381134 reaction equation
[Br:1]Br.[C:3]([O:6][CH2:7][CH2:8][N:9]1[CH:13]=[N:12][N:11]=[N:10]1)(=[O:5])[CH3:4]>C(Cl)(Cl)Cl.C(O)(=O)C>[C:3]([O:6][CH2:7][CH2:8][N:9]1[C:13]([Br:1])=[N:12][N:11]=[N:10]1)(=[O:5])[CH3:4]

Participants

5

Reactant 2

HCID 24408BromineHCID 2834192-(1h-tetrazol-1-yl)ethyl acetate

Product 1

HCID 54007007HCID 54007007, compoundYield 94.7%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 6212ChloroformSolvent2×

Procedure

Bromine (69.1 g) in chloroform (80 ml) was added to a stirred refluxing solution of 1H-tetrazole-1-ethanol acetate (ester) (33.8 g) in acetic acid (200 ml) and chloroform (400 ml). After 72 h the mixture was cooled and evaporated, excess, saturated potassium carbonate solution was added and the mixture was extracted with ethyl acetate to give the title compound (48.2 g) as a cream solid, m.p. 55°-6° (from diethyl ether).

Workup

  1. temperatureAfter 72 h the mixture was cooled
  2. customevaporated
  3. additionexcess, saturated potassium carbonate solution was added
  4. extractionthe mixture was extracted with ethyl acetate

Sources & evidence

ORD record
ord-7984b71061f04479b97807e20d02da1a
Source dataset
uspto-grants-1986_04
Patent number
US04585781

Reaction notes

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