HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → 2-(2,4-dichlorophenyl)-3-(2-[N,N-dimethylcarbamoyl]ethylthio)-1-(1H-1,2,4-triazol-1-yl)-propan-2-ol hydrochloride hemihydrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | N-Hydroxysuccinimide | HCID 80170 | — |
| Reactant | 2-(2,4-dichlorophenyl)-3-(2-carboxyethylthio)-1-(1H-1,2,4-triazol-1-yl)-propan-2-ol | HCID 23323745 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-(2,4-dichlorophenyl)-3-(2-[N,N-dimethylcarbamoyl]ethylthio)-1-(1H-1,2,4-triazol-1-yl)-propan-2-ol hydrochloride hemihydrate | HCID 131714175 | — |
Reaction Steps
2-(2,4-Dichlorophenyl)-3-(2-carboxyethylthio)-1-(1H-1,2,4-triazol-1-yl)-propan-2-ol (0.38 g) was suspended in dioxan whilst N-hydroxysuccinimide (0.172 g, 1.5 equiv.) and dicyclohexylcarbodiimide (0.309 g, 1.5 equiv.) were added. The reaction mixture was stirred overnight (19 hours) at room temperature. Anhydrous dimethylamine (0.09 g, 2.0 equiv.) was added, and stirring continued for 30 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04585778 |
| Source dataset | uspto-grants-1986_04 |
| ORD ID | ord-7d255d7778bd4334b2152d8f4225dc72 |
| Source note | uspto-grants-1986_04 |