Acetic Anhydride → HCID 86740746, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1.67 g of (-)-cis-2-(4-methoxyphenyl)-3-hydroxy-5-[2-(N-tert.-butoxycarbonyl-N-methylamino)ethyl]-8-chloro-2,3-dihydro-1,5-benzothiazepin-4(5H)-one, 15 ml of acetic anhydride and 0.5 ml of pyridine is stirred at 110° C. for 4 hours. Then, the mixture is evaporated under reduced pressure to remove solvent. Benzene is added to the residue, and the mixture is evaporated under reduced pressure to remove solvent. 1.81 g of (-)-cis-2-(4-methoxylphenyl)-3-acetoxy-5-[2-(N-tert.-butoxycarbonyl-N-methylamino)ethyl]-8-chloro-2,3-dihydro-1,5-benzothiazepin-4(5H)-one are obtained as an oil.

Provenance & Evidence