HCID 131714643, compound → HCID 70494567, compound

Participants

Reaction Steps

735 mg of (-)-cis-2-(4-methoxyphenyl)-3-acetoxy-5-[2-(N-methylamino)ethyl]-9-chloro-2,3-dihydro-1,5-benzothiazepin-4(5H)-one.hydrochloride are dissolved in 15 ml of 25% HCl-ethanol, and the solution is stirred at room temperature for 3 hours. The mixture is evaporated under reduced pressure to remove solvent. The residue is washed with ether and recrystallized from methanol. 622 mg of (+)-cis-2-(4-methoxyphenyl)-3-hydroxy-5-[2-(N-methylamino)ethyl]-9-chloro-2,3-dihydro-1,5-benzothiazepin-4(5H)-one.hydrochloride are obtained.

Provenance & Evidence