反应详情

30 Grams of o-nitroaniline and 55.7 g of anhydrous chloroacetic acid were mixed together and the mixture was heated at 70° to 80° C. for 30 minutes with stirring, then water was added to the reaction mixture, the crystals thus formed were collected by filtration and recrystallized from isopropyl ether to obtain 49.42 g of o-nitro-α-chloroacetanilide in the form of light yellow flake-like crystals. Melting point: 85.5°-87.0° C.

1. temperaturethe mixture was heated at 70° to 80° C. for 30 minutes
2. customthe crystals thus formed
3. filtrationwere collected by filtration
4. customrecrystallized from isopropyl ether