HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxybenzamide → HCID 13320258, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxybenzamide | HCID 65052 | — |
| Reactant | 3-Benzyl-6-oxa-3-azabicyclo(3.1.0)hexane | HCID 9815370 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 13320258 | HCID 13320258 | 19% |
Reaction Steps
A mixture of 28 g. of 1-benzyl-3,4-epoxypyrrolidine and 20.6 g. of 4-hydroxybenzamide was heated at 130° C. for 8 hrs. The cooled mixture was columned on silica gel using 5% methanol in ethyl acetate to elute the product, which was then crystallized from chloroform-benzene-methanol. The yield was 19% of product melting at 133.0°-6.0° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04585785 |
| Source dataset | uspto-grants-1986_04 |
| ORD ID | ord-f4b31b39c579481088b02cc5a28f1d2e |
| Source note | uspto-grants-1986_04 |