HCID 13320263, compound → HCID 13192218, compound

HRID 1381232Notes

Reaction equation

HRID 1381232 reaction equation
C([N:8]1[CH2:12][CH:11]([O:13][C:14]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[CH:17]=[CH:16][CH:15]=2)[CH:10]([OH:24])[CH2:9]1)C1C=CC=CC=1>[Pd].C(O)C>[C:14]1([O:13][C@@H:11]2[CH2:12][NH:8][CH2:9][C@H:10]2[OH:24])[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:17]=[CH:16][CH:15]=1

Participants

4

Reactant 1

HCID 13320263HCID 13320263, compound

Product 1

HCID 13192218HCID 13192218, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Eighteen grams of 1-benzyl-4-(1-naphthoxy)-3-pyrrolidinol in 200 ml. of ethanol was treated with ca. 2 g. of 10% palladium-on-charcoal under hydrogen at 60° C. for 20 hr. The mixture was cooled filtered and ethanol removed. The residue was crystallized from benzene and had a melting point of 112°-115° C.

Workup

  1. temperatureThe mixture was cooled
  2. filtrationfiltered
  3. customethanol removed
  4. customThe residue was crystallized from benzene

Sources & evidence

ORD record
ord-6a3910accd9845d7b342fa6ecdf38e4e
Source dataset
uspto-grants-1986_04
Patent number
US04585785

Reaction notes

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