Methyl (11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetate → HCID 12330037, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 3.5 g. of methyl 6,11-dihydro-11oxodibenz[b,e]oxepin-2-acetate in 150 ml. of dry ether is added dropwise to suspension of 2.5 g. of lithium aluminum hydride in 50 ml. of dry ether. The mixture is refluxed for three hours, cooled to 0° C., and hydrolyzed. The mixture is extracted with ether, dried over sodium sulfate, and evaporated to a crude crystalline product. Recrystallization from acetonitrile provides colorless crystals, m.p. 135°-137° C. of 6,11-dihydro-11-hydroxydibenz-[b,e]oxepin-2-ethanol.

Provenance & Evidence