Water → HCID 54086302, compound

Participants

Reaction Steps

5 g of 5-(3-aminopropyl)-2-thiophenecarboxamide and 3.4 ml of (S)-phenylethylene oxide were stirred at 95° for 26 hours in 68 ml of dimethyl sulphoxide. The mixture was poured into 200 ml of water and extracted three times with 150 ml of methylene chloride. The methylene chloride solutions were washed with water, dried and evaporated in vacuo. Chromatography of the residue on silica gel with ether/methanol gave 2.85 g of 5-[3-[bis-[(S)-β-hydroxyphenethyl]amino]propyl]-2-thiophenecarboxamide; [α]D =+76° (c=0.1% in dioxan); UV: ε277 =10390.

Provenance & Evidence