Sodium Hydroxide → HCID 70451836, compound

Participants

Reaction Steps

850 mg of 5-[3-[bis-[(R)-β-hydroxyphenethyl]amino]propyl]-2-thiophenecarboxamide and 300 mg of lithium aluminum hydride were boiled at reflux for 1.5 hours in 60 ml of tetrahydrofuran. The mixture was treated cautiously with 2N sodium hydroxide solution and extracted three times with ether. The ether solutions were washed neutral with water, dried and evaporated. Chromatography of the residue on silica gel with methanol gave 650 mg of 5-[3-[bis-[(R)-β-hydroxyphenethyl]amino]propyl]-2-aminomethyl-thiophene.

Provenance & Evidence