2-[3-(Trifluoromethyl)phenyl]oxirane → HCID 86740750, compound

Participants

Reaction Steps

5 g of ethyl (E)-5-[(RS)-2-aminopropyl]-β-methyl-2-thiopheneacrylate and 3.7 g of m-(trifluoromethyl)phenylethylene oxide were stirred at 90° for 22 hours in 50 ml of dimethyl sulphoxide. A further 1.23 g of m-(trifluoromethyl)phenylethylene oxide were added and the mixture was heated to 90° for a further 19 hours. The working-up was carried out in analogy to Example 4. Chromatography on silica gel gave ethyl (E)-5-[(RS)-2-[bis-[(RS)-β-hydroxy-m-(trifluoromethyl)phenethyl]amino]propyl]-β-methyl-2-thiopheneacrylate; ε323 =17310.

Provenance & Evidence