Phosgene → HCID 23324009, compound

Participants

Reaction Steps

By working in a manner similar to that described in Example 6, but starting from 3-(4-methoxyanilino)propionic acid (2.88 g; 14.7 mmol), methylene chloride (20 cc) and phosgene (4.3 g; 43.5 mmol), almost pure N-chloroformyl-3-(4-methoxyanilino)propionic acid (3.77 g) is obtained in the form of a white powder which melts at 90° C. After recrystallisation in a hexane/ethyl acetate mixture (50:50 by volume), the product melts at 93° C. The structure of the product obtained is confirmed by the infrared spectrum, mass spectrum and proton nuclear magnetic resonance spectrum.

Provenance & Evidence