Acrylic Acid → 3-(4-Methoxy-phenylamino)-propionic acid

HRID 1381283Notes

Reaction equation

HRID 1381283 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[CH:5][CH:4]=1.[C:10]([OH:14])(=[O:13])[CH:11]=[CH2:12]>O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][CH2:12][CH2:11][C:10]([OH:14])=[O:13])=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 6581Acrylic AcidHCID 7732P-Anisidine

Product 1

HCID 24326633-(4-Methoxy-phenylamino)-propionic acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3-(4-Methoxyanilino)propionic acid is prepared in a manner similar to that described in Example 1 but starting from p-anisidine (61 g; 0.495 mole), acrylic acid (9.5 g; 0.132 mole) and water (12 cc). After recrystallisation in toluene, the pure product (11.7 g; 0.060 mole) is obtained in the form of a white powder which melts at 89° C.

Workup

  1. customAfter recrystallisation in toluene
  2. customthe pure product (11.7 g; 0.060 mole) is obtained in the form of a white powder which melts at 89° C.

Sources & evidence

ORD record
ord-024927a86f0b49c59f59ca90b096251d
Source dataset
uspto-grants-1986_04
Patent number
US04585867

Reaction notes

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