Phosgene → N-chloroformyl-3-(m-chloroanilino)propionic acid

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Reaction Steps

A process of the preparation of 7-chloro-1,2,3,4-tetrahydro-4-quinolinone which comprises treating 3-(m-chloro-anilino)propionic acid with phosgene to produce N-chloroformyl-3-(m-chloroanilino)propionic acid, converting the said product, by the action of an organic base or by heating, into 3-(m-chlorophenyl)-2,6-dioxo-1,3-perhydrooxazine, and treating the latter with aluminium chloride in an inert organic solvent or with a strong acid, to provide 7-chloro-1,2,3,4-tetrahydro-4-quinolinone.

Provenance & Evidence