Chloride → HCID 54345317, compound

Participants

Reaction Steps

2.34 g of 1-(3-oxo-2,6,6-trimethyl-1-cyclohexen-1-yl)-3-methyl-1,4-pentadien-3-ol were dissolved in 15 ml of hexane and 5 ml of diethyl ether, treated with 2 drops of tricaprylm thylammonium chloride and 4.54 ml of aqueous potassium hydroxide solution (prepared from 70 g of powdered potassium hydroxide and 50 ml of water) and stirred well. 1.98 g of dimethyl sulphate were subsequently added to the mixture and the course of the reaction was followed by gas chromatography. After stirring at room temperature for 4 hours (product/educt ratio 99.7:0.3), the mixture was poured on to ice. The organic phase was separated, washed neutral with water, dried over sodium sulphate and concentrated under a water-jet vacuum. There were obtained 2.47 g of 1-(3-oxo-2,6,6-trimethyl-1-cyclohexen-1-yl)-3-methoxy-3-methyl-1,4-pentadiene as a yellow oil.

Provenance & Evidence