Phosphorus oxychloride → 2-Chloro-6-(2-chlorophenyl)-5-(4-chlorophenyl)nicotinonitrile

Participants

Reaction Conditions

Reaction Steps

To the product of Step B (1.5 g) was added POCl3 (5 mL). The reaction was heated to 100° C. for 17 hours. After cooling to room temperature the excess POCl3 was removed in vacuo before the residue was dissolved in EtOAc and washed with saturated aqueous NaHCO3 solution. The solution was concentrated and purified via flash chromatography on silica gel eluted with 10% EtOAc in hexane affording the title compound. HPLC/MS: 358.9 (M+1), 360.9 (M+3); Rt=4.07 min.

Provenance & Evidence