HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 4-{[(Benzyloxy)carbonyl]amino}-5-chloro-2-methoxybenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 11142640 | HCID 11142640 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-{[(Benzyloxy)carbonyl]amino}-5-chloro-2-methoxybenzoic acid | HCID 14403172 | — |
Reaction Steps
200 ml 2N aqueous sodium hydroxide solution is added dropwise to a stirred solution of 72.1 g of the benzoic acid methyl ester produced in step (b) in 800 ml dioxane. The mixture is stirred for 20 hours and the organic solvent removed under a vacuum. The residue is dissolved in water and adjusted to pH 5-6 with 3N hydrochloric acid. The heading compound is filtered off and washed with water. M.pt. 182°-183° (from methanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04803199 |
| Source dataset | uspto-grants-1989_02 |
| ORD ID | ord-f0b7cb2e551c4118addbfb318093c287 |
| Source note | uspto-grants-1989_02 |