Acetic Anhydride → HCID 21276160, compound

Participants

Reaction Steps

Cyclohepta[1,2-c]pyridine, N-oxide (24.00 g, 0.147 mole) was added portionwise to a stirred solution of acetic anhydride (140 ml). The resulting yellow mixture was then stirred for 2 hours at its reflux temperature and overnight at room temperature. Excess acetic anhydride was removed by evaporation at ~55° C. on a rotary evaporator and the dark brown, oily residue was distilled (170°, 0.03 mm) and chromatographed on silica gel eluting with a mixture of ethyl acetate in methylene chloride (1:4) to give the desired product.

Provenance & Evidence