2-(4-Chlorophenyl)ethylamine → HCID 21276119, compound

HRID 1381513Notes

Reaction equation

HRID 1381513 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][N:10]2[C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=3[C:14]([C:21](OCC)=[O:22])=[C:13](O)[CH2:12][S:11]2(=[O:28])=[O:27])[CH:5]=[CH:6][C:7]=1[Cl:8].[Cl:29][C:30]1[CH:38]=[CH:37][C:33]([CH2:34][CH2:35][NH2:36])=[CH:32][CH:31]=1>C1(C)C=CC=CC=1>[Cl:29][C:30]1[CH:38]=[CH:37][C:33]([CH2:34][CH2:35][NH:36][C:21]([C:14]2[C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[N:10]([CH2:9][C:4]3[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=3)[S:11](=[O:27])(=[O:28])[CH2:12][C:13]=2[NH:36][CH2:35][CH2:34][C:33]2[CH:37]=[CH:38][C:30]([Cl:29])=[CH:31][CH:32]=2)=[O:22])=[CH:32][CH:31]=1

Participants

4

Reactant 2

HCID 674302-(4-Chlorophenyl)ethylamineHCID 54693815HCID 54693815, compound

Product 1

HCID 21276119HCID 21276119, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 1.7 g of ethyl 1-(3,4-dichlorophenylmethyl)-1,3-dihydro-4-hydroxy-2,1-benzothiazepine-5-carboxylate-2,2-dioxide, 0.6 g of 4-chlorophenethylamine in 100 ml of toluene is heated at reflux for 2 days. The reaction mixture is evaporated to dryness. The residue is crystallized from ether - hexane (charcoal) to yield N-(4-chlorophenethyl)-1-(3,4-dichlorophenylmethyl)-1,3-dihydro-4-(4-chlorophenethylamino)-2,1-benzothiazepine-5-carboxamide-2,2-dioxide; m.p. 119°-121°.

Workup

  1. temperatureis heated
  2. temperatureat reflux for 2 days
  3. customThe reaction mixture is evaporated to dryness
  4. customThe residue is crystallized from ether - hexane (charcoal)

Sources & evidence

ORD record
ord-b883381964d444a7acac0241559b13e9
Source dataset
uspto-grants-1989_02
Patent number
US04803197

Reaction notes

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