Water → beta-[[3-(1-Methylethoxy)propyl]amino]-alpha-phenylbenzeneethanol

Participants

Reaction Conditions

Reaction Steps

A mixture of trans-stilbene oxide (1.96 g, 0.010 mole) and 3-isopropoxy-1-propylamine (3.51 g, 0.030 mole) was heated at 140° C. for 5 hrs. After standing at ambient temperature for 18 hrs the mixture was dissolved in acetone (20 ml) and the solution poured into water (120 ml). A solid formed rapidly and was collected by filtration and dried at ambient temperature. The solid (2.80 g, 89%) was recrystallized from toluene-isooctone to yield 2.08 g of a fluffy white solid, m.p. 106°-108° C.

Provenance & Evidence