Water → beta-[[3-(2-Methylpropoxy)propyl]amino]-alpha-phenylbenzeneethanol

Participants

Reaction Conditions

Reaction Steps

A mixture of trans-stilbene oxide (91.96 g, 0.10 mole) and 3-isobutoxy-1-propylamine (3.93 g, 0.030 mole) was heated at 140° C. for 5 hrs. After standing at ambient temperature for 18 hrs the mixture was dissolved in acetone (20 ml) and the solution poured into water (120 ml). A solid formed rapidly which was collected by filtration and dried under ambient conditions to obtain 2.89 g (88%) of the desired product. Recrystallization from tolueneisooctone gave 2.44 g of an off-white solid, m.p. 90°-92° C.

Provenance & Evidence