HCID 14391175, compound → HCID 21276121, compound

HRID 1381535Notes

Reaction equation

HRID 1381535 reaction equation
Cl.[CH3:2][O:3][CH2:4][CH2:5][NH:6][CH:7]([CH3:16])[C:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:9]>C(Cl)Cl>[CH3:2][O:3][CH2:4][CH2:5][NH:6][CH:7]([CH3:16])[CH:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[OH:9]

Participants

3

Reactant 1

HCID 14391175HCID 14391175, compound

Product 1

HCID 21276121HCID 21276121, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2-[(2-Methoxyethyl)amino]-1-phenyl-1-propanone hydrochloride as prepared in Preparation 5 is converted to the free base by mixing it with methylene chloride and a dilute basic aqueous solution, e.g., sodium hydroxide, separating the organic layer and evaporating the solvent. The residue, the free base is then reduced with sodium borohydride in ethanol to give the title compound which is then isolated by conventional means.

Workup

  1. customa dilute basic aqueous solution, e.g., sodium hydroxide, separating the organic layer
  2. customevaporating the solvent

Sources & evidence

ORD record
ord-b056282931ab498ea2cb0dfa6e770fd3
Source dataset
uspto-grants-1989_02
Patent number
US04803200

Reaction notes

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