Ammonia → HCID 178492221, compound

Participants

Reaction Steps

4,5-dihydro-1-phenylmethyl-1H-pyrazol-3-amine (24 g) (prepared by the method of H. Dorm, A. Otto, Chem Ber. 103 2505 (1970), p-anisidine (17.5 g) and p-toluenesulphonic acid (100 mg) was heated at 170° under dry nitrogen until evolution of ammonia ceased. The reaction mix was cooled, purified by chromatography on SiO2 eluting with ether:pentane 1:1 to give the sub-title compound as colourless cubes (13.3 g).

Provenance & Evidence