反应详情

A solution of 7.0 g (0.038 mole) of 1-methyl-5-aminoindole-3-acetonitrile was treated with KOCN as in Example 1 to give a beige solid which was filtered off, washed with cold water and triturated with 50% aq. EtOH to give 6.95 g (80%) of a beige solid: m.p. 250° (dec); nmr (d6 -DMSO) δ(TMS) 8.41 (1, s), 7.65 (1, s), 7.42-7.08 (3, m), 5.73 (2, s, --NH2 --), 4.00 (2, s, --CH2 --) and 3.73 ppm (3H, S, N--CH3).

1. customto give a beige solid which
2. filtrationwas filtered off
3. washwashed with cold water
4. customtriturated with 50% aq. EtOH