Acetic Anhydride → HCID 12803112, compound

HRID 1381558Notes

Reaction equation

HRID 1381558 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH2:11][C:12]#[N:13].[C:14](OC(=O)C)(=[O:16])[CH3:15]>N1C=CC=CC=1>[C:12]([CH2:11][C:5]1[C:4]2[C:8](=[CH:9][CH:10]=[C:2]([NH:1][C:14](=[O:16])[CH3:15])[CH:3]=2)[NH:7][CH:6]=1)#[N:13]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 12803100HCID 12803100, compound

Product 1

HCID 12803112HCID 12803112, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A solution of 6.0 g (0.035 mole) of 5-aminoindole-3-acetonitrile, Example 1, in 30 ml pyridine was treated with 15 ml of acetic anhydride. After stirring 18 hours, the solvent was removed in vacuo and residue recrystallized twice from EtOH to yield 4.35 g of product: m.p. 176°-177°.

Workup

  1. customthe solvent was removed in vacuo and residue
  2. customrecrystallized twice from EtOH

Sources & evidence

ORD record
ord-97554ba202974d8cab449740c78f1fa7
Source dataset
uspto-grants-1989_02
Patent number
US04803218

Reaction notes

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