Ethyl bromoacetate → HCID 14053139, compound

HRID 1381586Notes

Reaction equation

[C:1]([C:4]1[CH:18]=[CH:17][C:7]([CH2:8][S:9][C:10]2[C:15]([OH:16])=[CH:14][CH:13]=[CH:12][N:11]=2)=[C:6]([CH2:19][CH2:20][CH3:21])[C:5]=1[OH:22])(=[O:3])[CH3:2].Br[CH2:24][C:25]([O:27][CH2:28][CH3:29])=[O:26]>>[C:1]([C:4]1[CH:18]=[CH:17][C:7]([CH2:8][S:9][C:10]2[C:15]([O:16][CH2:24][C:25]([O:27][CH2:28][CH3:29])=[O:26])=[CH:14][CH:13]=[CH:12][N:11]=2)=[C:6]([CH2:19][CH2:20][CH3:21])[C:5]=1[OH:22])(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 7748Ethyl bromoacetate

HCID 140531382-[(4-Acetyl-3-hydroxy-2-propylbenzyl)thio]-3-hydroxypyridine

Product 1

HCID 14053139HCID 14053139, compoundYield 70.8%

Procedure

Using as starting materials 0.10 g of 2-[(4-acetyl-3- hydroxy-2-propylbenzyl)thio]-3-hydroxypyridine obtained in Example 17 and 0.07 g of ethyl bromoacetate, 0.09 g of ethyl [[2-[(4-acetyl-3-hydroxy-2-propylbenzyl)thio]pyridin-3-yl]- oxy]acetate was obtained in a manner similar to Example 15.

Sources & evidence

ORD record: ord-78e0ee869f8b465ca39667333ff2303c
Source dataset: uspto-grants-1989_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04803211

Reaction notes

Loading…