Sodium Hydroxide → HCID 21276275, compound

HRID 1381622Notes

Reaction equation

HRID 1381622 reaction equation
[C:1]1([CH2:7][O:8][C:9]2[CH:10]=[C:11]([CH2:23][CH2:24][N:25]([CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][S:38][CH2:39][CH2:40][C:41]3[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=3)C(=O)C(F)(F)F)[CH:12]=[CH:13][C:14]=2[O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>C(O)C>[C:41]1([CH2:40][CH2:39][S:38][CH2:37][CH2:36][CH2:35][CH2:34][CH2:33][CH2:32][NH:25][CH2:24][CH2:23][C:11]2[CH:12]=[CH:13][C:14]([O:15][CH2:16][C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)=[C:9]([O:8][CH2:7][C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[CH:10]=2)[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 19838167HCID 19838167, compound

Product 1

HCID 21276275HCID 21276275, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The product from step (b) (7.0 g, 0.011 mole) was heated to reflux for 2 hr with a solution of sodium hydroxide (0.93 g, 0.023 mole) in 90% ethanol (100 ml). The cooled solution was concentrated in vacuo and the residue diluted with water and extracted with dichloromethane. The extracts were washed with water, dried (MgSO4) and evaporated. The residue was dissolved in ether and treated with ethereal-HCl to give the sub-title compound as the hydrochloride salt, a white solid (5.5 g) mp 89°-91°.

Workup

  1. concentrationThe cooled solution was concentrated in vacuo
  2. additionthe residue diluted with water
  3. extractionextracted with dichloromethane
  4. washThe extracts were washed with water
  5. dry with materialdried (MgSO4)
  6. customevaporated
  7. dissolutionThe residue was dissolved in ether
  8. additiontreated with ethereal-HCl

Sources & evidence

ORD record
ord-bb3ea4d6c3f946dead91b8dbc5e9ea36
Source dataset
uspto-grants-1989_02
Patent number
US04803225

Reaction notes

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