Potassium Fluoride → Ethyl 2,4-dinitro-5-fluorophenoxyacetate

HRID 1381639노트

반응식

HRID 1381639 반응식
[N+:1]([C:4]1[CH:16]=[C:15]([N+:17]([O-:19])=[O:18])[C:14](Cl)=[CH:13][C:5]=1[O:6][CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])([O-:3])=[O:2].[F-:21].[K+]>CN(C)C=O>[N+:1]([C:4]1[CH:16]=[C:15]([N+:17]([O-:19])=[O:18])[C:14]([F:21])=[CH:13][C:5]=1[O:6][CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])([O-:3])=[O:2]

참가 물질

4

반응물 2

HCID 522689Potassium FluorideHCID 14423666Ethyl 2,4-dinitro-5-chlorophenoxyacetate

생성물 1

HCID 14423667Ethyl 2,4-dinitro-5-fluorophenoxyacetate수율 74%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
122 °C

실험 절차

A suspension of ethyl 2,4-dinitro-5-chlorophenoxyacetate (2.0 g) and potassium fluoride (0.76 g) in N,N-dimethylformamide (10 g) was stirred at a temperature of 122° C. for 1.5 hours. After cooling, the reaction mixture was diluted with ice water (200 ml) and extracted with ethyl acetate. The organic layer was washed with water and saturated sodium chloride solution in order, dried over anhydrous magnesium sulfate and concentrated to give ethyl 2,4-dinitro-5-fluorophenoxyacetate (1.4 g; yield, 74.0%).

후처리

  1. temperatureAfter cooling
  2. extractionextracted with ethyl acetate
  3. washThe organic layer was washed with water and saturated sodium chloride solution in order
  4. dry with materialdried over anhydrous magnesium sulfate
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-37640bf011034ffb8b774cd03d64c4f9
출처 데이터셋
uspto-grants-1989_02
특허 번호
US04803270

반응 노트

불러오는 중…