Ethyl 2,4-dinitro-5-fluorophenoxyacetate → 7-Fluoro-6-amino-2H-1,4-benzoxazin-3(4H)-one

Participants

Reaction Steps

A suspension of ethyl 2,4-dinitro-5-fluorophenoxyacetate (1.3 g) and 5% palladium-carbon (0.35 g) in ethanol (30 ml) was subjected to catalytic reduction at room temperature under an ordinary pressure until 600 ml of hydrogen was absorbed. The reaction mixture was filtered, and the filtrate was concentrated to give 7-fluoro-6-amino-2H-1,4-benzoxazin-3(4H)-one (0.68 g; yield, 82.8%).

Provenance & Evidence