反应详情

10% Palladium on charcoal (1.5 g) was added to a solution of ethyl 2-(2-fluoro-4-benzyloxyphenoxy)propionate (13 g) in ethanol (250 ml) and the stirred suspension was placed under hydrogen at atmospheric pressure for 2 hours. The catalyst was removed by filtration and the filtrate evaporated under reduced pressure to give the product, ethyl 2-(2-fluoro-4-hydroxyphenoxy)propionate, as a colourless oil (8.9 g, 95%). Proton magnetic resonance spectrum (CDCl3, δ in ppm): 1.3, t, 3H, (CH2CH3); 1.6, d, 3H (--CHCH3); 4.25, q, 2H (OCH2CH3); 4.7, q, 1H (--CHCH3); 6.4-7.1, m, 4H (OH and phenoxy ring).

1. customThe catalyst was removed by filtration
2. customthe filtrate evaporated under reduced pressure