6-Bromo-2-chloroquinoxaline → Ethyl 2-[2-fluoro-4-(6-bromoquinoxalin-2-yloxy)phenoxy]propionate
Reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7](Cl)[CH:6]=[N:5]2.[F:13][C:14]1[CH:27]=[C:26]([OH:28])[CH:25]=[CH:24][C:15]=1[O:16][CH:17]([CH3:23])[C:18]([O:20][CH2:21][CH3:22])=[O:19]>>[F:13][C:14]1[CH:27]=[C:26]([O:28][C:7]2[CH:6]=[N:5][C:4]3[C:9](=[CH:10][CH:11]=[C:2]([Br:1])[CH:3]=3)[N:8]=2)[CH:25]=[CH:24][C:15]=1[O:16][CH:17]([CH3:23])[C:18]([O:20][CH2:21][CH3:22])=[O:19]Participants
3
Procedure
Ethyl 2-[2-fluoro-4-(6-bromoquinoxalin-2-yloxy)phenoxy]propionate (10) was prepared from 6-bromo-2-chloro quinoxaline and ethyl 2-(2-fluoro-4-hydroxyphenoxy)propionate following essentially the same procedure as that described in Example 1 part (b). The title compound was obtained as colourless crystals mp 107°-108.6° C. and the assigned structure was characterised by nuclear magnetic resonance spectroscopy.
Sources & evidence
- ORD record
- ord-a6f2e60002af4dc6889f2dc3a35eb699
- Source dataset
- uspto-grants-1989_02
- Patent number
- US04803273
Reaction notes
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