HCID 14294199, compound → HCID 14294239, compound

Participants

Reaction Steps

A suspension of 13.8 g of 3-[[5-(4-methylphenyl)-1,2,3-thiadiazol-4-yl]thio]propanoic acid, ethyl ester in 250 ml of dry ethanol was treated with 200 ml of 1M potassium ethoxide in ethanol. After standing 1.5 hours, the solvent was removed in vacuo to about 100 ml and 400 ml of anhydrous ether was added. The solid was collected, washed with ether, dissolved in methanol and filtered. The filtrate was concentrated to a small volume and then diluted with 400 ml of anhydrous ether. The solid was collected and dried in vacuo, giving 11.5 g of 5-(4-methylphenyl)-1,2,3-thiadiazole-4-thiol, monopotassium salt as a yellow solid, mp >125° C. (dec.).

Provenance & Evidence