Hydrochloric Acid → HCID 15592211, compound

Participants

Reaction Steps

The product from Example 10 (270 mg) was suspended in 10 ml of isopropyl alcohol and warmed. 20 ml of tetrahydrofuran was added. 200 mg of lithium hydroxide monohydrate in 3 ml of water was added followed by an additional 5 ml of water. The reaction mixture was stirred at room temperature for about 20 hours and 20 ml of 10% hydrochloric acid was added. The organic solvents were removed using a rotary evaporator and the residue was extracted with two 50 ml portions of ethyl ether. The ether extracts were combined, dried over sodium sulfate, filtered and the solvent removed under a nitrogen gas stream. The product is a white solid identical with the product disclosed in Example 15 in U.S. Pat. No. 4,469,885.

Provenance & Evidence