Methanethiol → HCID 14402877, compound

Participants

Reaction Steps

Methyl mercaptan (1.9 g) is slowly introduced to a refluxing mixture composed of 4-chloromethyl-6-nitro-2H-1,4-benzoxazin-3(4H)-one (4.48 g), potassium carbonate (3.3 g) and methyl ethyl ketone (30 ml). The reaction mixture is refluxed for 5 hours, made free from methyl ethyl ketone by evaporation in vacuo, and the resultant residue is extracted with ethyl acetate. The extract is washed with saturated sodium carbonate aqueous solution and with water, dried over sodium sulfate, and condensed to ensure crystallization. The collected solid is washed with a small amount of ether to obtain 4-methylthiomethyl-6-nitro-2H-1,4-benzoxazin-3(4H)-one (2.3 g).

Provenance & Evidence