HCID 602132, compound → HCID 14071092, compound

HRID 1381827Notes

Reaction equation

HRID 1381827 reaction equation
[Cl:1][C:2]1[C:7]2[C:8](=[O:16])[O:9][C:10]([C:12]([F:15])([F:14])[F:13])=[N:11][C:6]=2[CH:5]=[CH:4][CH:3]=1.C(N(CC)[CH:20]=[CH:21][CH3:22])C>>[F:13][C:12]([F:15])([F:14])[C:10]1[C:21]([CH3:22])=[CH:20][C:5]2[C:6](=[C:7]([C:8]([OH:9])=[O:16])[C:2]([Cl:1])=[CH:3][CH:4]=2)[N:11]=1

Participants

3

Reactant 2

HCID 602132HCID 602132, compoundHCID 12773243N,N-Diethylprop-1-en-1-amine

Product 1

HCID 14071092HCID 14071092, compoundYield 41%

Procedure

2-trifluoromethyl-3-methyl-7-chloroquinoline-8-carboxylic acid of melting point 186°-188° C. is prepared, in a yield of 41%, from 5-chloro-2-trifluoromethyl-3,1-benzoxazin-4-one and 1-diethylaminoprop-1-ene, using a method similar to that described in Example 3.

Sources & evidence

ORD record
ord-a0c2ec9271004646b2617d2c8d07eaa8
Source dataset
uspto-grants-1989_02
Patent number
US04804404

Reaction notes

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