Nitric Acid → HCID 14071093, compound

HRID 1381828Notes

Reaction equation

HRID 1381828 reaction equation
[F:1][C:2]([F:21])([F:20])[C:3]1[C:12]([C:13]([F:16])([F:15])[F:14])=[CH:11][C:10]2C(=C(CBr)[C:7]([Cl:17])=[CH:8][CH:9]=2)[N:4]=1.S(=O)(=O)(O)O.[N+]([O-])(O)=O.[C:31]([OH:35])(=[O:34])[CH2:32][CH3:33]>O>[F:1][C:2]([F:20])([F:21])[C:3]1[C:12]([C:13]([F:15])([F:16])[F:14])=[CH:11][C:10]2[C:33](=[C:32]([C:31]([OH:35])=[O:34])[C:7]([Cl:17])=[CH:8][CH:9]=2)[N:4]=1

Participants

6

Reactant 4

HCID 944Nitric AcidHCID 1032Propionic AcidHCID 1118Sulfuric AcidHCID 14071097HCID 14071097, compound

Product 1

HCID 14071093HCID 14071093, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2.4 g of 2,3-bis-(trifluoromethyl)-8-bromomethyl-7-chloroquinoline are suspended in 6.8 g of propionic acid and 6.8 g of 70% strength sulfuric acid, and 5.5 g of 65% strength nitric acid are added dropwise at 120° C. After 2 hours at 120° C., the mixture is diluted with water and the precipitate is filtered off under suction, washed and dried; 1.7 g (84%) of 2,3-bis-(trifluoromethyl)-7-chloroquinoline-8-carboxylic acid of melting point 108°-111° C. are isolated.

Workup

  1. filtrationthe precipitate is filtered off under suction
  2. washwashed
  3. customdried

Sources & evidence

ORD record
ord-6aa6a28cd8e44a668f728eb610e657ae
Source dataset
uspto-grants-1989_02
Patent number
US04804404

Reaction notes

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