反应详情

A mixture of 46.5 g of 3-amino-4-fluorobenzoic acid and 37.8 g of dimethylmaleic anhydride in 200 ml of glacial acetic acid is stirred for 12 hours at an oil bath temperature of 130°-40°. After cooling, the mixture is poured onto ice-water, and the resulting precipitate is filtered with suction, washed with water and dried. Recrystallisation from ethanol/water yields 70.3 g of N-(2-fluoro-5-carboxyphenyl)-2,3-dimethylmaleic acid imide which melts at 238°-240°.

1. temperatureAfter cooling
2. additionthe mixture is poured onto ice-water
3. filtrationthe resulting precipitate is filtered with suction
4. washwashed with water
5. customdried
6. customRecrystallisation from ethanol/water