N-(2-fluoro-4-nitro-5-carboxyphenyl)-2,3-dimethylmaleic acid imide → N-(2-fluoro-5-carboxy-4-aminophenyl)-2,3-dimethylmaleic acid imide

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Reaction Steps

67.8 g of N-(2-fluoro-5-carboxy-4-nitrophenyl)-2,3-dimethylmaleic acid imide are hydrogenated using hydrogen in the presence of 14 g of Raney nickel catalyst in 1000 ml of tetrahydrofuran at a temperature of 20°-25° under normal pressure. When the stoichiometric amount of hydrogen has been consumed, the catalyst is separated off and the solution is concentrated by evaporation. 56.7 g of N-(2-fluoro-5-carboxy-4-aminophenyl)-2,3-dimethylmaleic acid imide having a melting point of 270° are thus obtained.

Provenance & Evidence