HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Amino-1-butyl-1,2,3,4-tetrahydropyrimidine-2,4-dione → 1-Butyl-5-nitroso-6-aminouracil
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Amino-1-butyl-1,2,3,4-tetrahydropyrimidine-2,4-dione | HCID 2428996 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-Butyl-5-nitroso-6-aminouracil | HCID 10798570 | — |
Reaction Steps
To 50.6 g (0.276 mol) of 6-amino-1-butyl-2,4-(1H,3H)-pyrimidinedione (VIII) dissolved in 1.8 l of wate at 80° C. was added 60 ml of 5N NCl and 20 g (0.29 mol) of NaNO2 which were dissolved in water. After cooling the red crystals were filtered off and washed with water. Yield 52.8 g (97%) (IX), NMR.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04804664 |
| Source dataset | uspto-grants-1989_02 |
| ORD ID | ord-bab59f9f5fbf4139bc0de5e6dd3548d4 |
| Source note | uspto-grants-1989_02 |