HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Butyl-5-nitroso-6-aminouracil → 5,6-Diamino-1-butylpyrimidine-2,4(1H,3H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Butyl-5-nitroso-6-aminouracil | HCID 10798570 | — |
| Catalyst | Adams' catalyst | HCID 345198 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5,6-Diamino-1-butylpyrimidine-2,4(1H,3H)-dione | HCID 10584108 | — |
Reaction Steps
52.8 g (0.27 mol) of 6-amino-1-butyl-5-nitroso-2,4-(1H,3H)-pyrimidinedione (IX) was dissolved in 1 l of DMF at 90° C. and catalytically hydrogenated in the presence of 0.1 g PtO2 for 18 hours and at room temperature and at a pressure of 200 KPa. The catalyst and the crystals were filtered off and washed with ethanol. Yield 36.6 g (67%) (X), NMR.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04804664 |
| Source dataset | uspto-grants-1989_02 |
| ORD ID | ord-849fd6c6a7ea493988580a44a0185fae |
| Source note | uspto-grants-1989_02 |