2-Fluorobenzoyl chloride → HCID 21275355, compound

HRID 1381877Notes

Reaction equation

HRID 1381877 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([Cl:6])=[O:5].[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)=[CH:14][CH:13]=1>C(Cl)Cl>[ClH:6].[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][N:20]2[CH2:21][CH2:22][N:23]([C:4](=[O:5])[C:3]3[CH:7]=[CH:8][CH:9]=[CH:10][C:2]=3[F:1])[CH2:24][CH2:25]2)=[CH:14][CH:13]=1

Participants

4

Reactant 2

HCID 98082-Fluorobenzoyl chlorideHCID 122357141-[2-(4-Chlorophenyl)ethyl]piperazine

Product 1

HCID 21275355HCID 21275355, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent3×

Procedure

A solution of 4.7 g of 2-fluorobenzoyl chloride in 20 ml of methylene chloride is added dropwise, over a period of 10 minutes, to a solution, stirred at room temperature, of 6.6 g of 1-[2-(4-chlorophenyl)-ethyl]-piperazine in 70 ml of methylene chloride. The reaction mixture is stirred overnight at room temperature, diluted with approximately 250 ml of methylene chloride, washed with sodium hydroxide solution and with water, dried over sodium sulphate and concentrated to dryness by evaporation. The residue is purified and characterised via the hydrochloride which has a melting point of 233°-235°. 1-[2-(4-chlorophenyl)-ethyl]-4-(2-fluorobenzoyl)-piperazine hydrochloride is thus obtained.

Workup

  1. washwashed with sodium hydroxide solution and with water
  2. dry with materialdried over sodium sulphate
  3. concentrationconcentrated to dryness by evaporation
  4. customThe residue is purified

Sources & evidence

ORD record
ord-4a3e0215c0864d1bbd730b4923673773
Source dataset
uspto-grants-1989_02
Patent number
US04804661

Reaction notes

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