HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 21275336, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 21275346 | HCID 21275346 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 21275336 | HCID 21275336 | — |
Reaction Steps
A solution of 1-[2-(4-chlorophenyl)-ethyl]-4-(3,5-diacetoxybenzoyl)-piperazine in 500 ml of methanol stirred with 285 ml of 1N NaOH for 16 hours at 20°. The reaction mixture is diluted with H2O and the pH is adjusted to 6 with acetic acid. The resulting oily precipitate is stirred with CH2Cl2 and filtered with suction. Crystallisation from ethanol yields 1-[2-(4-chlorophenyl)-ethyl]-4-(3,5-dihydroxybenzoyl)piperazine having a melting point of 217°-221°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04804661 |
| Source dataset | uspto-grants-1989_02 |
| ORD ID | ord-282e9ccfd63a4860b8e9c85f87345915 |
| Source note | uspto-grants-1989_02 |