Sodium Carbonate → HCID 3697829, compound

HRID 1381904Notes

Reaction equation

HRID 1381904 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.[CH2:11]([N:13]1[CH2:17][CH2:16][CH2:15][CH:14]1[CH2:18][NH2:19])[CH3:12].C(=O)([O-])[O-].[Na+].[Na+]>O>[CH2:11]([N:13]1[CH2:17][CH2:16][CH2:15][CH:14]1[CH2:18][NH:19][C:6](=[O:7])[C:5]1[CH:9]=[CH:10][C:2]([F:1])=[CH:3][CH:4]=1)[CH3:12]

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 678794-Fluorobenzoyl chlorideHCID 1172952-Aminomethyl-1-ethylpyrrolidine

Product 1

HCID 3697829HCID 3697829, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Add 5.05 g (31.8 mmol) of p-fluorobenzoyl chloride drop-wise to a 0° C. solution of 4.08 g (31.8 mmol) of 1-ethyl-2-(aminomethyl)pyrrolidine and 3.85 (35.0 mmol) of sodium carbonate in 50 mL of water. Stir the resultant solution at 0° C. for about 30 minutes, then at room temperature for about 20 hr. Extract the resultant solution with methylene chloride (2×100 mL). Dry the combined extracts with Na2SO4 and evaporate the solvent to give the title compound.

Workup

  1. extractionExtract the resultant solution with methylene chloride (2×100 mL)
  2. dry with materialDry the combined extracts with Na2SO4
  3. customevaporate the solvent

Sources & evidence

ORD record
ord-077fa705ae2c474db35fa06373f22e86
Source dataset
uspto-grants-1989_02
Patent number
US04804662

Reaction notes

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