HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → Methyl 4-(1H-imidazol-1-yl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 4-fluorobenzoate | HCID 67878 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Methyl 4-(1H-imidazol-1-yl)benzoate | HCID 2766374 | — |
Reaction Steps
Heat 101.6 g (0.65 mol) of methyl 4-fluorobenzoate, 66.65 g (0.98 mol) of imidazole, and 182.0 g (1.31 mol) of potassium carbonate in dimethylsulfoxide at ca. 120° C. for about 3 hr. Cool the solution to room temperature and pour into 500 mL of cold water. Filter to obtain crystals of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04804662 |
| Source dataset | uspto-grants-1989_02 |
| ORD ID | ord-8b1b20b9eff9404eaeaf5a0bb69692b0 |
| Source note | uspto-grants-1989_02 |