HCID 21275433, compound → HCID 21275429, compound

HRID 1381940Notes

Reaction equation

HRID 1381940 reaction equation
[ClH:1].C([O:9][N:10]1[C:14](=[O:15])[CH2:13][C:12]2([CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]2)[C:11]1=[O:22])C1C=CC=CC=1.[H][H]>CO.O.[Pd]>[ClH:1].[OH:9][N:10]1[C:14](=[O:15])[CH2:13][C:12]2([CH2:16][CH2:17][N:18]([CH3:21])[CH2:19][CH2:20]2)[C:11]1=[O:22]

Participants

5

Reactant 2

HCID 21275433HCID 21275433, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 21275429HCID 21275429, compoundYield 93%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 22242641Methanol--water (1/1)Solvent

Procedure

The compound No. 1 (2-benzyloxy-8-methyl-2,8-diazaspiro[4,5]decane-1,3-dione hydrochloride (6.4 g), listed in Table 1 in Example 4) was dissolved in 50 ml of methanol-water (1 to 1, v/v), and this was followed by catalytic hydrogen reduction for about 1 hour in the presence of palladium catalyst. The resulting solid was recrystallized from ethanol to obtain 4.3 g of a colorless crystal having a melting point of from 284° to 286° C.

Workup

  1. customThe resulting solid was recrystallized from ethanol

Sources & evidence

ORD record
ord-587011a698464ac68cc472fd1c7945c4
Source dataset
uspto-grants-1989_02
Patent number
US04804665

Reaction notes

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