Ammonia → HCID 178472081, compound

HRID 1382002Notes

Reaction equation

HRID 1382002 reaction equation
C(O[CH:4]=[C:5]([C:11](=[O:22])[C:12]1[CH:17]=[C:16]([F:18])[C:15]([F:19])=[C:14]([F:20])[C:13]=1[F:21])[C:6]([O:8][CH2:9][CH3:10])=[O:7])C.[NH3:23]>CCO>[NH2:23][CH:4]=[C:5]([C:11](=[O:22])[C:12]1[CH:17]=[C:16]([F:18])[C:15]([F:19])=[C:14]([F:20])[C:13]=1[F:21])[C:6]([O:8][CH2:9][CH3:10])=[O:7]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 54346083Ethyl 3-ethoxy-2-(2,3,4,5-tetrafluorobenzoyl)acrylate

Product 1

HCID 178472081HCID 178472081, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

12.8 g of ethyl 3-ethoxy-2-(2,3,4,5-tetrafluoro-benzoyl)-acrylate are initially introduced into 16 ml of EtOH. A mixture of 3.3 ml of concentrated aqueous NH3 solution and 10 ml of EtOH is added dropwise with ice cooling. The mixture is subsequentially stirred for 2 hours. Ice-water is then added, and the precipitated solid is filtered off under suction.

Workup

  1. additionis added dropwise with ice cooling
  2. filtrationthe precipitated solid is filtered off under suction

Sources & evidence

ORD record
ord-8d1d2f6b43f949cb8352562c4ac0a8fc
Source dataset
uspto-grants-1989_02
Patent number
US04804760

Reaction notes

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